IISER achieves genetic breakthrough

Brahmapur: In a significant advance in genetic diagnostics, researchers at IISER-Brahmapur have developed a nanotechnology-enabled biosensing platform capable of rapidly and sensitively detecting DNA sequences associated with Turner Syndrome, a rare chromosomal disorder caused by the complete or partial loss of one X chromosome in females.

The research, led by Dr Parikshit Moitra, Assistant Professor in the Department of Chemical Sciences, employs a nucleotide-guided covalent organic framework (COF) integrated with gold nanostars to create a highly sensitive biosensor. The platform uses molecular recognition and plasmonic nanotechnology to identify Turner Syndrome-specific genetic signatures with enhanced precision, offering a promising alternative to conventional chromosomal karyotyping, which is labour-intensive, time-consuming and dependent on specialised laboratory facilities.

Turner Syndrome affects nearly one in 2,500 female births and is associated with short stature, delayed puberty, infertility, and cardiovascular and renal abnormalities. Early diagnosis is crucial for timely medical intervention and improved long-term health outcomes.

Published in the internationally acclaimed journal ’Advanced Functional Materials,’ the study demonstrates the potential of the nanoplatform to transform genetic screening by enabling rapid, cost-effective and accessible DNA diagnostics. The researchers believe the technology can be adapted for the detection of other inherited genetic disorders, paving the way for broader applications in precision medicine.

The research team acknowledged the encouragement and support of Prof Ashok Kumar Ganguli, Director of IISER-Brahmapur. While the technology requires further clinical validation before routine medical application, it marks a major step towards next-generation molecular diagnostics and personalised healthcare.